反应详情

温度

95 °C

A solution of 12.6 ml (100 mmol) phenethylamine in 50 ml toluene was treated at RT with 7.4 ml (200 mmol) tert-butyl bromoacetate and heated at 95° C. for 4 h. After cooling (0° C.), filtration and evaporation of the filtrate, the residue was suspended in pentane, cooled (0° C.), filtrated and evaporated to give 11.5 g (98%) of phenethylamino-acetic acid tert-butyl ester as an oil, MS: 236 (MH+).

1. temperatureAfter cooling
2. filtration(0° C.), filtration and evaporation of the filtrate
3. temperaturecooled (0° C.)
4. filtrationfiltrated
5. customevaporated