HRID1264532

反应详情

EQUATION

反应方程式

REACTANTS

反应物

反应SMILES：C1=CC=CN(CCCNCc2ccc3c(c2)OCO3)C=C1

HCID18612648

未命名化合物

反应SMILES：Fc1cc(F)cc(-c2cc(N(CCCN3C=CC=CC=C3)Cc3ccc4c(c3)OCO4)on2)c1.O=C(O)C(F)(F)F

HCID86758907

未命名化合物

PRODUCTS

产物

反应SMILES：Fc1cc(F)cc(-c2cc(N(CCCN3C=CC=CC=C3)Cc3cccc4ccccc34)on2)c1.O=C(O)C(F)(F)F

HCID86758906

未命名化合物

PROCEDURE

实验过程

The title compound is prepared using a similar procedure as described for the preparation of 3,4-methylenedioxybenzyl-[3-(3,5-difluorophenyl)-isoxazol-5-yl]-(3-azepin-1-yl-propyl)-amine TFA salt (example 4) while substituting 1-Naphthylmethyl-(3-azepin-1-yl-propyl)-amine for 3,4-methylenedioxybenzyl-(3-azepin-1-yl-propyl)-amine.

来源与证据

来源类型: Open Reaction Database
ORD记录: ord-5ea2b0d885d249a182ff70b41b443b4e
来源数据集: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
专利号: US06544982B1
来源说明: uspto-grants-2003_04

反应SMILES

[OH:1][C:2]([C:4]([F:7])([F:6])[F:5])=[O:3].C1O[C:40]2[CH:39]=[CH:38][C:12]([CH2:13][N:14]([C:25]3[O:29][N:28]=[C:27]([C:30]4[CH:35]=[C:34]([F:36])[CH:33]=[C:32]([F:37])[CH:31]=4)[CH:26]=3)[CH2:15][CH2:16][CH2:17][N:18]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=[CH:19]3)=[CH:11][C:10]=2O1.C1O[C:61]2[CH:60]=CC(CNCCCN3C=CC=CC=C3)=[CH:45][C:44]=2O1>>[OH:3][C:2]([C:4]([F:7])([F:6])[F:5])=[O:1].[C:12]1([CH2:13][N:14]([C:25]2[O:29][N:28]=[C:27]([C:30]3[CH:35]=[C:34]([F:36])[CH:33]=[C:32]([F:37])[CH:31]=3)[CH:26]=2)[CH2:15][CH2:16][CH2:17][N:18]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=[CH:19]2)[C:11]2[C:10](=[CH:45][CH:44]=[CH:61][CH:60]=2)[CH:40]=[CH:39][CH:38]=1