3,4-Methylenedioxybenzyl-(3-azepin-1-yl-propyl)-amine → 1-Naphthylmethyl-[3-(3,5-difluorophenyl)-isoxazol-5-yl]-(3-azepin-1-yl-propyl)amine TFA salt

HRID 1264532Notes

Reaction equation

HRID 1264532 reaction equation
[OH:1][C:2]([C:4]([F:7])([F:6])[F:5])=[O:3].C1O[C:40]2[CH:39]=[CH:38][C:12]([CH2:13][N:14]([C:25]3[O:29][N:28]=[C:27]([C:30]4[CH:35]=[C:34]([F:36])[CH:33]=[C:32]([F:37])[CH:31]=4)[CH:26]=3)[CH2:15][CH2:16][CH2:17][N:18]3[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=[CH:19]3)=[CH:11][C:10]=2O1.C1O[C:61]2[CH:60]=CC(CNCCCN3C=CC=CC=C3)=[CH:45][C:44]=2O1>>[OH:3][C:2]([C:4]([F:7])([F:6])[F:5])=[O:1].[C:12]1([CH2:13][N:14]([C:25]2[O:29][N:28]=[C:27]([C:30]3[CH:35]=[C:34]([F:36])[CH:33]=[C:32]([F:37])[CH:31]=3)[CH:26]=2)[CH2:15][CH2:16][CH2:17][N:18]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=[CH:19]2)[C:11]2[C:10](=[CH:45][CH:44]=[CH:61][CH:60]=2)[CH:40]=[CH:39][CH:38]=1

Participants

3

Reactant 2

HCID 186126483,4-Methylenedioxybenzyl-(3-azepin-1-yl-propyl)-amineHCID 867589073,4-Methylenedioxybenzyl-[3-(3,5-difluorophenyl)-isoxazol-5-yl](3-azepin-1-yl-propyl)-amine TFA salt

Product 1

HCID 867589061-Naphthylmethyl-[3-(3,5-difluorophenyl)-isoxazol-5-yl]-(3-azepin-1-yl-propyl)amine TFA salt

Procedure

The title compound is prepared using a similar procedure as described for the preparation of 3,4-methylenedioxybenzyl-[3-(3,5-difluorophenyl)-isoxazol-5-yl]-(3-azepin-1-yl-propyl)-amine TFA salt (example 4) while substituting 1-Naphthylmethyl-(3-azepin-1-yl-propyl)-amine for 3,4-methylenedioxybenzyl-(3-azepin-1-yl-propyl)-amine.

Sources & evidence

ORD record
ord-5ea2b0d885d249a182ff70b41b443b4e
Source dataset
uspto-grants-2003_04
Patent number
US06544982B1

Reaction notes

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