反应详情

To a solution of 52.35 g (0.225 mol) of 4-hydroxybenzenesulfonate sodium salt in 1L of isopropanol and 225 mL of a 1.0N solution of sodium hydroxide was added 59.96 g (0.45 mol) of 1-bromo-2-butyne. The resulting mixture was heated to 70° for 15 h and then the isopropanol was removed by evaporation in vacuo. The resulting white precipitate was collected by filtration, washed with isopropanol and ether and dried under vacuum to give 56.0 g (100%) of 4-but-2-ynyloxybenzenesulfonic acid sodium salt as a white solid.

1. temperatureThe resulting mixture was heated to 70° for 15 h
2. customthe isopropanol was removed by evaporation in vacuo
3. filtrationThe resulting white precipitate was collected by filtration
4. washwashed with isopropanol and ether
5. customdried under vacuum