Dichloromethane → HCID 18613777, compound

HRID 1264897Notes

Reaction equation

HRID 1264897 reaction equation
O[CH2:2][C:3]1[C:4]([N:18]2[CH2:27][CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]2[CH3:28])=[N:5][C:6]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[N:7][C:8]=1[CH3:9].C(N(S(F)(F)[F:35])CC)C.[Cl:38]CCl>>[ClH:38].[F:35][CH2:2][C:3]1[C:4]([N:18]2[CH2:27][CH2:26][C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]2[CH3:28])=[N:5][C:6]([NH:10][C:11]2[CH:16]=[CH:15][C:14]([F:17])=[CH:13][CH:12]=2)=[N:7][C:8]=1[CH3:9]

Participants

4

Reactant 3

HCID 6344DichloromethaneHCID 123472(Diethylamino)sulfur trifluorideHCID 18613781HCID 18613781, compound

Product 1

HCID 18613777HCID 18613777, compoundYield 14%

Procedure

The same procedures as in Example 24 above were repeated using 5-hydroxymethyl-6-methyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine (0.19 g, 0.5mmol) prepared in accordance with WO 98/43968, dichloromethane (5 ml), and (diethylamino)sulfur trifluoride (0.15 ml, 2.26 mmol) to afford 27 mg (14%) of the titled compound.

Sources & evidence

ORD record
ord-197c824ddbf945628190a2cb1777cee1
Source dataset
uspto-grants-2003_04
Patent number
US06545008B1

Reaction notes

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