Dichloromethane → HCID 18613777, compound

Participants

Reaction Steps

The same procedures as in Example 24 above were repeated using 5-hydroxymethyl-6-methyl-2-(4-fluorophenylamino)-4-(1-methyl-1,2,3,4-tetrahydroisoquinolin-2-yl)pyrimidine (0.19 g, 0.5mmol) prepared in accordance with WO 98/43968, dichloromethane (5 ml), and (diethylamino)sulfur trifluoride (0.15 ml, 2.26 mmol) to afford 27 mg (14%) of the titled compound.

Provenance & Evidence