反应详情

温度

120 °C

A suspension of 2-aminonicotinic acid (1.0 g 7.24 mmol) in propionic anhydride (10 mL) of was heated to 120° C. for 1 h under nitrogen atmosphere. The temperature was increased to 167° C. to remove the propionic acid and propionic anhydride under reduced pressure. The resulting brown solid was triturated with hexane and dried to give the title pyrido-oxazine (16) (1.10 g, 86%) as a white solid:

1. temperatureThe temperature was increased to 167° C.
2. customto remove the propionic acid and propionic anhydride under reduced pressure
3. customThe resulting brown solid was triturated with hexane
4. customdried