4-(Trifluoromethyl)benzoyl chloride → HCID 18613818, compound

HRID 1264915Notes

Reaction equation

HRID 1264915 reaction equation
Cl.[NH2:2][CH2:3][C:4]([C:6]1[CH:16]=[CH:15][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][CH:7]=1)=[O:5].[F:17][C:18]([F:29])([F:28])[C:19]1[CH:27]=[CH:26][C:22]([C:23](Cl)=[O:24])=[CH:21][CH:20]=1>>[F:17][C:18]([F:28])([F:29])[C:19]1[CH:27]=[CH:26][C:22]([C:23]([NH:2][CH2:3][C:4]([C:6]2[CH:16]=[CH:15][C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][CH:7]=2)=[O:5])=[O:24])=[CH:21][CH:20]=1

Participants

3

Reactant 2

HCID 676074-(Trifluoromethyl)benzoyl chlorideHCID 18613865193813-77-3

Product 1

HCID 18613818HCID 18613818, compoundYield 53%

Procedure

In the same manner as in Reference Example 6, ethyl 4-(2-amino-1-oxoethyl)benzoate hydrochloride and 4-trifluoromethylbenzoyl chloride were condensed to obtain ethyl 4-[2-(4-trifluoromethylbenzoylamino)-1-oxoethyl]benzoate. Yield: 53%. NMR (CDCl3) δ 1.43 (3H, t, J=7 Hz), 4.43 (2H, q, J=7 Hz), 5.01 (2H, d, J=4 Hz), 7.31 (1H, brs), 7.75 (2H, d, J=8 Hz), 7.95-8.25 (6H, m).

Workup

  1. customcondensed

Sources & evidence

ORD record
ord-e77eb1f27e884b07835df0aab014f45e
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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