4-(Trifluoromethyl)benzoyl chloride → HCID 18613818, compound

Participants

Reaction Steps

In the same manner as in Reference Example 6, ethyl 4-(2-amino-1-oxoethyl)benzoate hydrochloride and 4-trifluoromethylbenzoyl chloride were condensed to obtain ethyl 4-[2-(4-trifluoromethylbenzoylamino)-1-oxoethyl]benzoate. Yield: 53%. NMR (CDCl3) δ 1.43 (3H, t, J=7 Hz), 4.43 (2H, q, J=7 Hz), 5.01 (2H, d, J=4 Hz), 7.31 (1H, brs), 7.75 (2H, d, J=8 Hz), 7.95-8.25 (6H, m).

Provenance & Evidence