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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1264918Generated: October 26, 2026

2-Bromo-4'-(trifluoromethyl)acetophenone → Methyl 4-[4-(4-trifluoromethylphenyl)-2-oxazolyl]benzoate

https://huagongshe.com/reaction/1264918

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-4'-(trifluoromethyl)acetophenoneHCID 321979—
ReactantMethyl 4-carbamoylbenzoateHCID 596094—
ProductMethyl 4-[4-(4-trifluoromethylphenyl)-2-oxazolyl]benzoateHCID 1861391130%

Reaction Steps

In the same manner as in Example 1, methyl 4-carbamoylbenzoate was reacted with 4-trifluoromethylphenacyl bromide to obtain methyl 4-[4-(4-trifluoromethylphenyl)-2-oxazolyl]benzoate. The product was recrystallized from ethanol. Yield: 30%. Pale yellow prisms. Melting Point: 182 to 183° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06545009B1
Source datasetuspto-grants-2003_04
ORD IDord-bf02b70999c5486b8c7a9af558dddc71
Source noteuspto-grants-2003_04