Methyl 4-carbamoylbenzoate → Methyl 4-[4-[3,5-bis(trifluoromethyl)phenyl]-2-oxazolyl]benzoate

HRID 1264926Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1264926
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[O:3])[NH2:2].[F:14][C:15]([F:31])([F:30])[C:16]1[CH:17]=[C:18]([CH:23]=[C:24]([C:26]([F:29])([F:28])[F:27])[CH:25]=1)[C:19](=O)[CH2:20]Br>>[F:14][C:15]([F:30])([F:31])[C:16]1[CH:17]=[C:18]([C:19]2[N:2]=[C:1]([C:4]3[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=3)[O:3][CH:20]=2)[CH:23]=[C:24]([C:26]([F:27])([F:28])[F:29])[CH:25]=1

Komponenten

3

Edukt 2

HCID 596094Methyl 4-carbamoylbenzoateHCID 27361703,5-Bis(trifluoromethyl)phenacyl bromide

Produkt 1

HCID 18613896Methyl 4-[4-[3,5-bis(trifluoromethyl)phenyl]-2-oxazolyl]benzoateAusbeute 24 %

Versuchsvorschrift

In the same manner as in Example 1, methyl 4-carbamoylbenzoate was reacted with 3,5-bis(trifluoromethyl)phenacyl bromide to obtain methyl 4-[4-[3,5-bis(trifluoromethyl)phenyl]-2-oxazolyl]benzoate. The product was. recrystallized from ethanol., Yield: 24%. Pale yellow prisms. Melting Point: 180 to 181° C.

Quellen und Nachweise

ORD-Eintrag
ord-2492970650f54ecea2dfc14bd594a39b
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06545009B1

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