反应详情

温度

85 °C

A mixture of methyl 4-thiocarbamoylbenzoate (1.56 g), 4-difluoromethoxyphenacyl bromide (2.65 g) and ethanol (15 ml) was stirred at 80 to 90° C. for 1 hour. The reaction mixture was cooled, and precipitated crystals were collected by filtration to obtain methyl 4-[4-(4-difluoromethoxyphenyl)-2-thiazolyl]benzoate (2.00 g, yield: 69%). The product was recrystallized from ethanol to obtain pale yellow prisms. Melting Point: 146 to 148° C.

1. temperatureThe reaction mixture was cooled
2. customprecipitated crystals
3. filtrationwere collected by filtration