Thionicotinamide → HCID 18613883, compound

HRID 1264932Notes

Reaction equation

HRID 1264932 reaction equation
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[N:4][CH:3]=1.[Br:10][CH2:11][C:12]([C:14]1[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=1)=O>>[BrH:10].[N:4]1[CH:5]=[CH:6][CH:7]=[C:2]([C:1]2[S:8][CH:11]=[C:12]([C:14]3[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=3)[N:9]=2)[CH:3]=1

Participants

3

Reactant 2

HCID 737155ThionicotinamideHCID 11966043Ethyl 4-(2-bromoacetyl)benzoate

Product 1

HCID 18613883HCID 18613883, compoundYield 67%

Procedure

In the same manner as in Example 28, thionicotinamide was reacted with ethyl 4-bromoacetylbenzoate to obtain ethyl 4-[2-(3-pyridyl)-4-thiazolyl]benzoate hydrobromide. The product was recrystallized from ethanol. Yield: 67%. Pale yellow prisms. Melting point: 234 to 236° C.

Sources & evidence

ORD record
ord-8d94ae42f12d40409bc6a634193b7d52
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

Loading…