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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1264934Generated: October 26, 2026

2-Bromo-4'-methylacetophenone → Methyl 4-[4-(4-methylphenyl)-2-thiazolyl]benzoate

https://huagongshe.com/reaction/1264934

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-4'-methylacetophenoneHCID 69272—
ReactantMethyl 4-carbamothioylbenzoateHCID 11401319—
ProductMethyl 4-[4-(4-methylphenyl)-2-thiazolyl]benzoateHCID 1861387161%

Reaction Steps

In the same manner as in Example 28, methyl 4-thiocarbamoylbenzoate was reacted with 4-methylphenacyl bromide to obtain methyl 4-[4-(4-methylphenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 61%. Pale yellow prisms. Melting point: 185 to 187° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06545009B1
Source datasetuspto-grants-2003_04
ORD IDord-0118f9dacc784107aa82bc912aaf8728
Source noteuspto-grants-2003_04