2-Bromo-1-(2-pyridinyl)-1-ethanone hydrobromide → HCID 18613913, compound

HRID 1264939Notes

Reaction equation

HRID 1264939 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].Br.[Br:15][CH2:16][C:17]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][N:20]=1)=O>>[BrH:15].[N:20]1[CH:21]=[CH:22][CH:23]=[CH:24][C:19]=1[C:17]1[N:2]=[C:1]([C:4]2[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=2)[S:3][CH:16]=1

Participants

3

Reactant 2

HCID 27762312-Bromo-1-(2-pyridinyl)-1-ethanone hydrobromideHCID 11401319Methyl 4-carbamothioylbenzoate

Product 1

HCID 18613913HCID 18613913, compoundYield 80%

Procedure

In the same manner as in Example 28, methyl 4-thiocarbamoylbenzoate was reacted with 2-bromoacetylpyridine hydrobromide to obtain methyl 4-[4-(2-pyridyl)-2-thiazolyl]benzoate hydrobromide. The product was recrystallized from ethanol. Yield: 80%. Pale yellow prisms. Melting point: 243 to 244° C.

Sources & evidence

ORD record
ord-d81fd3f63a934453b2ec38cdb41fd618
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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