2-Bromo-1-(pentafluorophenyl)ethan-1-one → HCID 18613824, compound

HRID 1264941Notes

Reaction equation

HRID 1264941 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].[F:14][C:15]1[C:24]([F:25])=[C:23]([F:26])[C:22]([F:27])=[C:21]([F:28])[C:16]=1[C:17](=O)[CH2:18]Br>>[F:14][C:15]1[C:24]([F:25])=[C:23]([F:26])[C:22]([F:27])=[C:21]([F:28])[C:16]=1[C:17]1[N:2]=[C:1]([C:4]2[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=2)[S:3][CH:18]=1

Participants

3

Reactant 2

HCID 27759632-Bromo-1-(pentafluorophenyl)ethan-1-oneHCID 11401319Methyl 4-carbamothioylbenzoate

Product 1

HCID 18613824HCID 18613824, compoundYield 60%

Procedure

In the same manner as in Example 28, methyl 4-thiocarbamoylbenzoate was reacted with 2,3,4,5,6-pentafluorophenacyl bromide to obtain methyl 4-[4-(2,3,4,5,6-pentafluorophenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 60%. Pale yellow prisms. Melting point: 141 to 142° C.

Sources & evidence

ORD record
ord-7913757938084c16b952af0405113729
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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