2-Bromo-3'-chloroacetophenone → HCID 18613875, compound

HRID 1264942Notes

Reaction equation

HRID 1264942 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].[Cl:14][C:15]1[CH:16]=[C:17]([CH:22]=[CH:23][CH:24]=1)[C:18](=O)[CH2:19]Br>>[Cl:14][C:15]1[CH:16]=[C:17]([C:18]2[N:2]=[C:1]([C:4]3[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=3)[S:3][CH:19]=2)[CH:22]=[CH:23][CH:24]=1

Participants

3

Reactant 2

HCID 387382-Bromo-3'-chloroacetophenoneHCID 11401319Methyl 4-carbamothioylbenzoate

Product 1

HCID 18613875HCID 18613875, compoundYield 72%

Procedure

In the same manner as in Example 28, methyl 4-thiocarbamoylbenzoate was reacted with 3-chlorophenacyl bromide to obtain methyl 4-[4-(3-chlorophenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 72%. Pale yellow prisms. Melting point: 150 to 151° C.

Sources & evidence

ORD record
ord-fd2201c6ac3e40c9b0a6084c51af2514
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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