HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Bromo-4'-(trifluoromethyl)acetophenone → Methyl 3-[4-(4-trifluoromethylphenyl)-2-thiazolyl]benzoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Bromo-4'-(trifluoromethyl)acetophenone | HCID 321979 | — |
| Reactant | Methyl 3-carbamothioylbenzoate | HCID 23279244 | — |
| Product | Methyl 3-[4-(4-trifluoromethylphenyl)-2-thiazolyl]benzoate | HCID 18613836 | 74% |
Reaction Steps
In the same manner as in Example 28, methyl 3-thiocarbamoylbenzoate was reacted with 4-trifluoromethylphenacyl bromide to obtain methyl 3-[4-(4- trifluoromethylphenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 74%. Colorless prisms. Melting point: 142 to 143° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06545009B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-db1c9f8b586c4246907109b6df682cfd |
| Source note | uspto-grants-2003_04 |