2-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-one → HCID 18613861, compound

HRID 1264944Notes

Reaction equation

HRID 1264944 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])(=[S:3])[NH2:2].[F:14][C:15]([F:27])([F:26])[C:16]1[CH:17]=[C:18]([CH:23]=[CH:24][CH:25]=1)[C:19](=O)[CH2:20]Br>>[F:14][C:15]([F:26])([F:27])[C:16]1[CH:17]=[C:18]([C:19]2[N:2]=[C:1]([C:4]3[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=3)[C:7]([O:9][CH3:10])=[O:8])[S:3][CH:20]=2)[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 27783862-Bromo-1-[3-(trifluoromethyl)phenyl]ethan-1-oneHCID 23279244Methyl 3-carbamothioylbenzoate

Product 1

HCID 18613861HCID 18613861, compoundYield 72%

Procedure

In the same manner as in Example 28, methyl 3-thiocarbamoylbenzoate was reacted with 3-trifluoromethylphenacyl bromide to obtain methyl 3-[4-(3-trifluoromethylphenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 72%. Colorless prisms. Melting point: 105 to 106° C.

Sources & evidence

ORD record
ord-51771fffc8214589b284eb6f1a6ac3a9
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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