Bromomethyl 4-methoxyphenyl ketone → HCID 18613878, compound

HRID 1264946Notes

Reaction equation

HRID 1264946 reaction equation
[C:1]([C:4]1[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=1)[C:7]([O:9][CH3:10])=[O:8])(=[S:3])[NH2:2].[CH3:14][O:15][C:16]1[CH:25]=[CH:24][C:19]([C:20](=O)[CH2:21]Br)=[CH:18][CH:17]=1>>[CH3:14][O:15][C:16]1[CH:25]=[CH:24][C:19]([C:20]2[N:2]=[C:1]([C:4]3[CH:5]=[C:6]([CH:11]=[CH:12][CH:13]=3)[C:7]([O:9][CH3:10])=[O:8])[S:3][CH:21]=2)=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 4965Bromomethyl 4-methoxyphenyl ketoneHCID 23279244Methyl 3-carbamothioylbenzoate

Product 1

HCID 18613878HCID 18613878, compoundYield 74%

Procedure

In the same manner as in Example 28, methyl 3-thiocarbamoylbenzoate was reacted with 4-methoxyphenacyl bromide to obtain methyl 3-[4-(4-methoxyphenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 74%. Pale yellow prisms. Melting point: 108 to 109° C.

Sources & evidence

ORD record
ord-1ba504dbe30c473d856200cc43878cd4
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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