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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1264949Generated: October 29, 2026

2-Bromo-3'-trifluoromethoxyacetophenone → Methyl 3-[4-(3-trifluoromethoxyphenyl)-2-thiazolyl]benzoate

https://huagongshe.com/reaction/1264949

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-3'-trifluoromethoxyacetophenoneHCID 2778687—
ReactantMethyl 3-carbamothioylbenzoateHCID 23279244—
ProductMethyl 3-[4-(3-trifluoromethoxyphenyl)-2-thiazolyl]benzoateHCID 1861381234%

Reaction Steps

In the same manner as in Example 28, methyl 3-thiocarbamoylbenzoate was reacted with 3-trifluoromethoxyphenacyl bromide to obtain methyl 3-[4-(3-trifluoromethoxyphenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 34%. Colorless prisms. Melting point: 84 to 85° C.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06545009B1
Source datasetuspto-grants-2003_04
ORD IDord-afaa23b1415f431aaba2402cfc99bcb0
Source noteuspto-grants-2003_04