Methyl 4-carbamothioylbenzoate → Methyl 4-[4-(2,5-dimethyl-3-furyl)-2-thiazolyl]benzoate

HRID 1264951Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 1264951
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].Br[CH2:15][C:16]([C:18]1[CH:22]=[C:21]([CH3:23])[O:20][C:19]=1[CH3:24])=O>>[CH3:24][C:19]1[O:20][C:21]([CH3:23])=[CH:22][C:18]=1[C:16]1[N:2]=[C:1]([C:4]2[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=2)[S:3][CH:15]=1

Komponenten

3

Edukt 2

HCID 11401319Methyl 4-carbamothioylbenzoateHCID 186138692-Bromo-1-(2,5-dimethylfuran-3-yl)ethan-1-one

Produkt 1

HCID 18613829Methyl 4-[4-(2,5-dimethyl-3-furyl)-2-thiazolyl]benzoateAusbeute 36 %

Versuchsvorschrift

In the same manner as in Example 74, methyl 4-thiocarbamoylbenzoate was reacted with 3-bromoacetyl-2,5-dimethylfuran to obtain methyl 4-[4-(2,5-dimethyl-3-furyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 36%. Pale yellow prisms. Melting point: 103 to 105° C.

Quellen und Nachweise

ORD-Eintrag
ord-1de763cc337a4c25ab7b0b079e2cc011
Quelldatensatz
uspto-grants-2003_04
Patentnummer
US06545009B1

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