Ethanone, 2-bromo-1-(2,5-dimethyl-3-thienyl)- → HCID 18613912, compound

HRID 1264952Notes

Reaction equation

HRID 1264952 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].Br[CH2:15][C:16]([C:18]1[CH:22]=[C:21]([CH3:23])[S:20][C:19]=1[CH3:24])=O>>[CH3:24][C:19]1[S:20][C:21]([CH3:23])=[CH:22][C:18]=1[C:16]1[N:2]=[C:1]([C:4]2[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=2)[S:3][CH:15]=1

Participants

3

Reactant 2

HCID 11241770Ethanone, 2-bromo-1-(2,5-dimethyl-3-thienyl)-HCID 11401319Methyl 4-carbamothioylbenzoate

Product 1

HCID 18613912HCID 18613912, compoundYield 64%

Procedure

In the same manner as in Example 74, methyl 4-thiocarbamoylbenzoate was reacted with 3-bromoacetyl-2,5-dimethylthiophene to obtain methyl 4-[4-(2,5-dimethyl-3-thienyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 64%. Pale yellow pritsms. Melting point: 109 to 110° C.

Sources & evidence

ORD record
ord-23fe72b46c964f6abe8f4998f3a40034
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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