Methyl 4-carbamothioylbenzoate → HCID 18613879, compound

HRID 1264953Notes

Reaction equation

HRID 1264953 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].Br[CH2:15][C:16]([C:18]1[CH:22]=[C:21]([Cl:23])[S:20][C:19]=1[Cl:24])=O>>[Cl:24][C:19]1[S:20][C:21]([Cl:23])=[CH:22][C:18]=1[C:16]1[N:2]=[C:1]([C:4]2[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=2)[S:3][CH:15]=1

Participants

3

Reactant 2

HCID 11401319Methyl 4-carbamothioylbenzoateHCID 18521789HCID 18521789, compound

Product 1

HCID 18613879HCID 18613879, compoundYield 74%

Procedure

In the same manner as in Example 74, methyl 4-thiocarbamoylbenzoate was reacted with 3-bromoacetyl-2,5-dichlorothiophene to obtain methyl 4-[4-(2,5-dichloro-3-thienyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 74%. Pale yellow prisms. Melting point: 149 to 150° C.

Sources & evidence

ORD record
ord-d60062fb682445f6b1b00f998d4fdf51
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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