2-Bromo-1-(4-tert-butylphenyl)ethan-1-one → Methyl 4-[4-(4-t-butylphenyl)-2-thiazolyl]benzoate

HRID 1264956Notes

Reaction equation

HRID 1264956 reaction equation
[C:1]([C:4]1[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=1)(=[S:3])[NH2:2].[C:14]([C:18]1[CH:27]=[CH:26][C:21]([C:22](=O)[CH2:23]Br)=[CH:20][CH:19]=1)([CH3:17])([CH3:16])[CH3:15]>>[C:14]([C:18]1[CH:19]=[CH:20][C:21]([C:22]2[N:2]=[C:1]([C:4]3[CH:13]=[CH:12][C:7]([C:8]([O:10][CH3:11])=[O:9])=[CH:6][CH:5]=3)[S:3][CH:23]=2)=[CH:26][CH:27]=1)([CH3:17])([CH3:16])[CH3:15]

Participants

3

Reactant 2

HCID 23247702-Bromo-1-(4-tert-butylphenyl)ethan-1-oneHCID 11401319Methyl 4-carbamothioylbenzoate

Product 1

HCID 18613899Methyl 4-[4-(4-t-butylphenyl)-2-thiazolyl]benzoateYield 68%

Procedure

In the same manner as in Example 74, methyl 4-thiocarbamoylbenzoate was reacted with 4-t-butylphenacyl bromide to obtain methyl 4-[4-(4-t-butylphenyl)-2-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 68%. Pale yellow prisms. Melting point: 154 to 155° C.

Sources & evidence

ORD record
ord-638df5004e54440e84b29432bc584bc1
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

Loading…