Thiobenzamide → HCID 18613890, compound

HRID 1264959Notes

Reaction equation

HRID 1264959 reaction equation
[C:1]([NH2:9])(=[S:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.Br[CH2:11][C:12]([C:14]1[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=1)=O>>[C:2]1([C:1]2[S:8][CH:11]=[C:12]([C:14]3[CH:24]=[CH:23][C:17]([C:18]([O:20][CH2:21][CH3:22])=[O:19])=[CH:16][CH:15]=3)[N:9]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 683563ThiobenzamideHCID 11966043Ethyl 4-(2-bromoacetyl)benzoate

Product 1

HCID 18613890HCID 18613890, compoundYield 68%

Procedure

In the same manner as in Example 74, thiobenzamide was reacted with ethyl 4-bromoacetylbenzoate to obtain ethyl 4-(2-phenyl-4-thiazolyl]benzoate. The product was recrystallized from ethanol. Yield: 68%. Pale yellow prisms. Melting point: 72 to 73° C.

Sources & evidence

ORD record
ord-6b10f47eab52463a819abebdac917915
Source dataset
uspto-grants-2003_04
Patent number
US06545009B1

Reaction notes

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