Phosphorus oxychloride → HCID 18613856, compound

HRID 1264965Notes

Reaction equation

[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([CH2:8][NH:9][C:10]([C:12]2[CH:22]=[CH:21][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:14][CH:13]=2)=[O:11])=O)=[CH:4][CH:3]=1.P(Cl)(Cl)(Cl)=O>>[Cl:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]2[O:11][C:10]([C:12]3[CH:22]=[CH:21][C:15]([C:16]([O:18][CH2:19][CH3:20])=[O:17])=[CH:14][CH:13]=3)=[N:9][CH:8]=2)=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 24813Phosphorus oxychloride

HCID 18613888HCID 18613888, compound

Product 1

HCID 18613856HCID 18613856, compoundYield 80%

Procedure

In the same manner as in Example 106, ethyl 4-[N-(4-chlorobenzoylmethyl)carbamoyl]benzoate was reacted with phosphorus oxychloride to obtain ethyl 4-[5-(4-chlorophenyl)-2-oxazolyl]benzoate. The product was recrystallized from ethyl acetate-isopropyl ether. Yield: 80%. Pale yellow prisms. Melting point: 195 to 197° C.

Sources & evidence

ORD record: ord-4aeb7d6030074696abcd4091a6590f1a
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06545009B1

Reaction notes

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