Dimethylcarbamoyl Chloride → N'-[2-(4-amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)ethyl]-N,N-dimethylurea

HRID 1265095Notes

Reaction equation

[CH3:1][N:2]([CH3:6])[C:3](Cl)=[O:4].[NH2:7][CH2:8][CH2:9][N:10]1[C:18]2[C:17]([CH3:19])=[C:16]([CH3:20])[N:15]=[C:14]([NH2:21])[C:13]=2[N:12]=[C:11]1[CH3:22]>>[NH2:21][C:14]1[C:13]2[N:12]=[C:11]([CH3:22])[N:10]([CH2:9][CH2:8][NH:7][C:3](=[O:4])[N:2]([CH3:6])[CH3:1])[C:18]=2[C:17]([CH3:19])=[C:16]([CH3:20])[N:15]=1

Participants

Reactant 2

HCID 6598Dimethylcarbamoyl Chloride

HCID 219738201-(2-aminoethyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine

Product 1

HCID 22397372N'-[2-(4-amino-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-1-yl)ethyl]-N,N-dimethylurea

Procedure

Using the method of Examples 118-133, dimethylcarbamyl chloride was reacted with 1-(2-aminoethyl)-2,6,7-trimethyl-1H-imidazo[4,5-c]pyridin-4-amine to provide the desired compound. The observed accurate mass was 291.1929.

Sources & evidence

ORD record: ord-a1975648fa1345e791b36655f6233df4
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06545017B1

Reaction notes

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