N-[3-(2-bromoacetyl)phenyl]methanesulfonamide → (+/-)-N-[3-(2-bromo-1-hydroxyethyl)phenyl]methanesulfonamide

HRID 1265211Notes

Reaction equation

HRID 1265211 reaction equation
[Br:1][CH2:2][C:3]([C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:6]=1)=[O:4]>CO.C(Cl)(Cl)Cl>[Br:1][CH2:2][CH:3]([C:5]1[CH:6]=[C:7]([NH:11][S:12]([CH3:15])(=[O:14])=[O:13])[CH:8]=[CH:9][CH:10]=1)[OH:4]

Participants

3

Reactant 1

HCID 11346858N-[3-(2-bromoacetyl)phenyl]methanesulfonamide

Product 1

HCID 18615063(+/-)-N-[3-(2-bromo-1-hydroxyethyl)phenyl]methanesulfonamide

Reagents, catalysts & solvents 1

HCID 21584188Chloroform methanolSolvent

Procedure

The above-identified compound (50.76 g) was obtained by processing Intermediate 14 (45 g) through reaction and after-treatment in accordance with the procedures of synthesis of Intermediate 41. Rf=0.27 (methanol/chloroform of 1/10).

Workup

  1. customthrough reaction

Sources & evidence

ORD record
ord-3e5457bc3184484582942ecbb1c89b3d
Source dataset
uspto-grants-2003_04
Patent number
US06545053B1

Reaction notes

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