1,4-Dioxane hydrochloride → HCID 69991419, compound

HRID 1265212Notes

Reaction equation

HRID 1265212 reaction equation
[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][CH2:15][CH2:16][NH:17][CH2:18][C@@H:19]([C:28]1[CH:29]=[CH:30][C:31]([F:39])=[C:32]([NH:34][S:35]([CH3:38])(=[O:37])=[O:36])[CH:33]=1)[O:20][Si](CC)(CC)CC.[ClH:40].O1CCOCC1>O1CCCC1>[ClH:40].[CH:1]1[C:13]2[NH:12][C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:5]=2[CH:4]=[CH:3][C:2]=1[O:14][CH2:15][CH2:16][NH:17][CH2:18][C@@H:19]([C:28]1[CH:29]=[CH:30][C:31]([F:39])=[C:32]([NH:34][S:35]([CH3:38])(=[O:36])=[O:37])[CH:33]=1)[OH:20]

Participants

4

Reactant 2

HCID 204431481,4-Dioxane hydrochlorideHCID 53853656HCID 53853656, compound

Product 1

HCID 69991419HCID 69991419, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Intermediate 102 (243 mg) was dissolved in anhydrous tetrahydrofuran (15 ml), whereto 4 N hydrogenchloride/1,4-dioxane (1 ml) was added and the mixture was agitated at room temperature for 1 hour. The deposited precipitate was taken out and washed with tetrahydrofuran, whereupon it was dried under a reduced pressure at 40° C., whereby the above-identified compound was obtained (96.8 mg).

Workup

  1. washwashed with tetrahydrofuran, whereupon it
  2. customwas dried under a reduced pressure at 40° C.
  3. customwhereby the above-identified compound was obtained (96.8 mg)

Sources & evidence

ORD record
ord-64b41e682dfd47108222210b9fa3c1ab
Source dataset
uspto-grants-2003_04
Patent number
US06545053B1

Reaction notes

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