HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tributylphosphine → Tributylphosphanium chloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tributylphosphine | HCID 13831 | — |
| Reactant | Merrifield's peptide resin | HCID 16211592 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Tributylphosphanium chloride | HCID 21584914 | — |
Reaction Steps
Merrifield's peptide resin (Aldrich, 1.1 meq/g of Cl), 50.1 g was stirred in 250 mL of CH2Cl2 with 132.3 g of tri-n-butylphosphine under argon for 1 week. The slurry was filtered and the beads washed with 1.5 L of CH2Cl2. The product was dried in the air and then under vacuum to produce 61.9 g of tributylphosphonium chloride substituted polymer.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06545102B1 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-2a7355b955e047119205471d407054e8 |
| Source note | uspto-grants-2003_04 |