反应详情

Merrifield's peptide resin (Aldrich, 1.1 meq/g of Cl), 50.1 g was stirred in 250 mL of CH2Cl2 with 132.3 g of tri-n-butylphosphine under argon for 1 week. The slurry was filtered and the beads washed with 1.5 L of CH2Cl2. The product was dried in the air and then under vacuum to produce 61.9 g of tributylphosphonium chloride substituted polymer.

1. filtrationThe slurry was filtered
2. washthe beads washed with 1.5 L of CH2Cl2
3. customThe product was dried in the air