反应详情

Iron powder (2.3 g) was added to a solution of 1-(4-chloro-6-fluoro-3-hydroxy-2-nitrophenyl)-4-(3-fluoropropyl)-1,4-dihydro-5-oxo-5H-tetrazole (3.4 g) in acetic acid (50 ml) and stirred at room temperature over night. The reaction mixture was filtered through a celite bed. The filtrate was concentrated under reduced pressure and purified by a silica gel column, eluted with hexane-ethyl acetate (2:1) to give yellow crystals (2.75 g).

1. filtrationThe reaction mixture was filtered through a celite bed
2. concentrationThe filtrate was concentrated under reduced pressure
3. custompurified by a silica gel column
4. washeluted with hexane-ethyl acetate (2:1)