Isopropyl iodide → HCID 18615655, compound

HRID 1265356Notes

Reaction equation

HRID 1265356 reaction equation
[NH2:1][C:2]1[C:7]([OH:8])=[C:6]([Cl:9])[CH:5]=[C:4]([F:10])[C:3]=1[N:11]1[C:15](=[O:16])[N:14]([CH2:17][CH2:18][CH2:19][F:20])[N:13]=[N:12]1.[CH:21](I)([CH3:23])[CH3:22].C(=O)([O-])[O-].[K+].[K+]>C(#N)C>[NH2:1][C:2]1[C:7]([O:8][CH:21]([CH3:23])[CH3:22])=[C:6]([Cl:9])[CH:5]=[C:4]([F:10])[C:3]=1[N:11]1[C:15](=[O:16])[N:14]([CH2:17][CH2:18][CH2:19][F:20])[N:13]=[N:12]1

Participants

5

Reactant 3

HCID 6362Isopropyl iodideHCID 11430Potassium CarbonateHCID 135854273HCID 135854273, compound

Product 1

HCID 18615655HCID 18615655, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The mixture of 1-(2-amino-4-chloro-6-fluoro-3-hydroxyphenyl)-4-(3-fluoropropyl)-1,4-dihydro-5-oxo-5H-tetrazole (0.30 g), isopropyl iodide (1.2 ml), and potassium carbonate (0.14 g) in acetonitrile (5 ml) was heated under reflux for 2 hours. The reaction mixture was evaporated and purified by a silica gel column, eluted with hexane-ethyl acetate (2:1) to give the desired product (0.29 g).

Workup

  1. temperaturewas heated
  2. temperatureunder reflux for 2 hours
  3. customThe reaction mixture was evaporated
  4. custompurified by a silica gel column
  5. washeluted with hexane-ethyl acetate (2:1)

Sources & evidence

ORD record
ord-d83934d44eeb425c956ec8107b905eb5
Source dataset
uspto-grants-2003_04
Patent number
US06545161B2

Reaction notes

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