反应详情

A reaction solution of N-(2-amino-4-chlorophenyl) phthalimide (0.5 g), triethylamine (0.28 g) and 2-naphthoyl chloride (0.35 g) in anhydrous tetrahydrofuran (50 ml) was heated at reflux temperature for 6 hr under nitrogen atmosphere. The resulting mixture was poured into water and extracted with ethyl acetate. The organic layer was washed with brine (×2) and dried over anhydrous sodium sulfate. The solvent was removed and the residue was purified by column chromatography on silica gel using ethyl acetate-hexane (1:5) to give the title compound (0.35 g) as a yellow solid.

1. temperatureat reflux temperature for 6 hr under nitrogen atmosphere
2. extractionextracted with ethyl acetate
3. washThe organic layer was washed with brine (×2)
4. dry with materialdried over anhydrous sodium sulfate
5. customThe solvent was removed
6. customthe residue was purified by column chromatography on silica gel