Dimethylamine → HCID 69688196, compound

HRID 1265504Notes

Reaction equation

HRID 1265504 reaction equation
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12](Cl)[C:11]([I:15])=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:3])[CH3:2].[CH3:20][NH:21][CH3:22]>C1COCC1>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([N:21]([CH3:22])[CH3:20])[C:11]([I:15])=[CH:10][C:9]=1[N+:16]([O-:18])=[O:17])([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 674DimethylamineHCID 21349844HCID 21349844, compound

Product 1

HCID 69688196HCID 69688196, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The title compound was prepared from (5-chloro-4-iodo-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example B1) (399 mg, 1 mmol) and dimethylamine (5.6 N in EtOH, 0.36 mL, 2 mmol) in THF (3 mL) at 65° C. for 18 h in a sealed tube according to the general procedure C. Obtained as a yellow solid (386 mg).

Sources & evidence

ORD record
ord-fa5b311607044b7db412dae815a8e6cb
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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