HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylamine → (5-Dimethylamino-4-fluoro-2-nitro-phenyl)-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylamine | HCID 674 | — |
| Reactant | tert-Butyl (5-chloro-4-fluoro-2-nitrophenyl)carbamate | HCID 46738284 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | (5-Dimethylamino-4-fluoro-2-nitro-phenyl)-carbamic acid tert.-butyl ester | HCID 69688435 | — |
Reaction Steps
The title compound was prepared from (5-chloro-4-fluoro-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example B6) (4.94 g, 17 mmol) and Me2NH (40% in H2O, 7.9M, 10.9 mL, 86 mmol) in DMSO (35 mL) at 23° C. according to the general procedure C. Obtained as a yellow solid (4.93 g).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-3f15e8ff6bd940e58f72cb258efab604 |
| Source note | uspto-grants-2003_04 |