Stannous chloride dihydrate → (2-Amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester

HRID 1265543Notes

Reaction equation

HRID 1265543 reaction equation
[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([Cl:17])=[CH:10][C:9]=1[N+:18]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:21])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([Cl:17])=[CH:10][C:9]=1[NH2:18])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 69688404(4-Chloro-5-dimethylamino-2-nitro-phenyl)-carbamic acid tert.-butyl ester

Product 1

HCID 69688689(2-Amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester

Procedure

The title compound was prepared from (4-chloro-5-dimethylamino-2-nitro-phenyl)-carbamic acid tert.-butyl ester (Example C1) (2.76 g, 8.74 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as an orange solid (2.3 g).

Sources & evidence

ORD record
ord-e391e61a525642a2a08026629e4d5569
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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