Stannous chloride dihydrate → Carbamic acid,[2-amino-4-chloro-5-(ethylmethylamino)phenyl]-,1,1-dimethylethyl ester

HRID 1265549Notes

Reaction equation

HRID 1265549 reaction equation
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH2:16][CH3:17])[CH3:15])[C:11]([Cl:18])=[CH:10][C:9]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH2:16][CH3:17])[CH3:15])[C:11]([Cl:18])=[CH:10][C:9]=1[NH2:19])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 69689605[4-Chloro-5-(ethyl-methyl-amino)-2-nitro-phenyl]-carbamic acid tert-butyl ester

Product 1

HCID 69688249Carbamic acid,[2-amino-4-chloro-5-(ethylmethylamino)phenyl]-,1,1-dimethylethyl ester

Procedure

The title compound was prepared from [4-chloro-5-(ethyl-methyl-amino)-2-nitro-phenyl]-carbamic acid tert-butyl ester (Example C5) (3.0 g, 9.09 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as a pale brown solid (2.64 g).

Sources & evidence

ORD record
ord-52739c48d22b4986b497b4fffe5cca68
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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