Stannous chloride dihydrate → Carbamic acid,[2-amino-4-chloro-5-(diethylamino)phenyl]-,1,1-dimethylethyl ester

HRID 1265551Notes

Reaction equation

HRID 1265551 reaction equation
[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[C:11]([Cl:19])=[CH:10][C:9]=1[N+:20]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:23])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH2:17][CH3:18])[CH2:15][CH3:16])[C:11]([Cl:19])=[CH:10][C:9]=1[NH2:20])([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 69688544[4-Chloro-5-(diethyl-amino)-2-nitro-phenyl]-carbamic acid tert-butyl ester

Product 1

HCID 69688145Carbamic acid,[2-amino-4-chloro-5-(diethylamino)phenyl]-,1,1-dimethylethyl ester

Procedure

The title compound was prepared from [4-chloro-5-(diethyl-amino)-2-nitro-phenyl]-carbamic acid tert-butyl ester (Example C7) (2.25 g, 6.54 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as an orange solid (1.55 g).

Sources & evidence

ORD record
ord-144f72ea58c44af995ec147a9d966e33
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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