(2-Dimethylamino-2'-fluoro-5-nitro-biphenyl-4-yl)-carbamic acid tert-butyl ester → HCID 69489440, compound

HRID 1265562Notes

Reaction equation

HRID 1265562 reaction equation
[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1[C:13]([N+:14]([O-])=O)=[CH:12][C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])=[C:10]([N:24]([CH3:26])[CH3:25])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]>[Pd]>[C:1]([O:5][C:6](=[O:27])[NH:7][C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:17]2[CH:22]=[CH:21][CH:20]=[CH:19][C:18]=2[F:23])=[C:10]([N:24]([CH3:25])[CH3:26])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

3

Reactant 1

HCID 69489429(2-Dimethylamino-2'-fluoro-5-nitro-biphenyl-4-yl)-carbamic acid tert-butyl ester

Product 1

HCID 69489440HCID 69489440, compound

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

The title compound was prepared from (2-dimethylamino-2′-fluoro-5-nitro-biphenyl-4-yl)-carbamic acid tert.-butyl ester (Example C18) (4.54 g, 12.1 mmol) by hydrogenation with 10% Pd/C according to the general procedure J (method a). Obtained as a light brown solid (3.324 g).

Sources & evidence

ORD record
ord-7e9dc96e1dfe496fb4bee129860bb76c
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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