Stannous chloride dihydrate → (2-Amino-4-cyano-5-dimethylamino-phenyl)-carbamic acid tert-butyl ester

HRID 1265565Notes

Reaction equation

HRID 1265565 reaction equation
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([C:17]#[N:18])=[CH:10][C:9]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:15])[CH3:16])[C:11]([C:17]#[N:18])=[CH:10][C:9]=1[NH2:19])([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 69688410HCID 69688410, compound

Product 1

HCID 69687295(2-Amino-4-cyano-5-dimethylamino-phenyl)-carbamic acid tert-butyl ester

Procedure

The title compound was prepared from (4-cyano-5-dimethylamino-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example C20) (3.9 g, 12.7 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as a pale brown solid (2.05 g, 58%).

Sources & evidence

ORD record
ord-79cbe37a1aab475699806928fafa7d10
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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