Stannous chloride dihydrate → Carbamic acid,[2-amino-4-cyano-5-(methylpropylamino)phenyl]-,1,1-dimethylethyl ester

HRID 1265571Notes

Reaction equation

HRID 1265571 reaction equation
[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:18])[CH2:15][CH2:16][CH3:17])[C:11]([C:19]#[N:20])=[CH:10][C:9]=1[N+:21]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:24])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:18])[CH2:15][CH2:16][CH3:17])[C:11]([C:19]#[N:20])=[CH:10][C:9]=1[NH2:21])([CH3:2])([CH3:3])[CH3:4]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 69687961[4-Cyano-5-(methyl-propyl-amino)-2-nitro-phenyl]-carbamic acid tert-butyl ester

Product 1

HCID 69688948Carbamic acid,[2-amino-4-cyano-5-(methylpropylamino)phenyl]-,1,1-dimethylethyl ester

Procedure

The title compound was prepared from [4-cyano-5-(methyl-propyl-amino)-2-nitro-phenyl]-carbamic acid tert-butyl ester (Example C26) (1.64 g, 4.90 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as a dark red oil (1.24 g, 83%).

Sources & evidence

ORD record
ord-52156d2833584d29930eb87d9eab8c4c
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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