Stannous chloride dihydrate → (2-Amino-4-chloro-5-isopropylamino-phenyl)-carbamic acid tert-butyl ester

HRID 1265582Notes

Reaction equation

HRID 1265582 reaction equation
[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([NH:14][CH:15]([CH3:17])[CH3:16])[C:11]([Cl:18])=[CH:10][C:9]=1[N+:19]([O-])=O)([CH3:4])([CH3:3])[CH3:2].O.O.Cl[Sn]Cl>>[C:1]([O:5][C:6](=[O:22])[NH:7][C:8]1[CH:13]=[C:12]([NH:14][CH:15]([CH3:16])[CH3:17])[C:11]([Cl:18])=[CH:10][C:9]=1[NH2:19])([CH3:2])([CH3:4])[CH3:3]

Participants

3

Reactant 2

HCID 61436Stannous chloride dihydrateHCID 69688645(4-Chloro-5-isopropylamino-2-nitro-phenyl)-carbamic acid tert-butyl ester

Product 1

HCID 69688623(2-Amino-4-chloro-5-isopropylamino-phenyl)-carbamic acid tert-butyl ester

Procedure

The title compound was prepared from (4-chloro-5-isopropylamino-2-nitro-phenyl)-carbamic acid tert-butyl ester (Example C37) (3.75 g, 11.3 mmol) by reduction with SnCl2.2H2O according to the general procedure J (method b). Obtained as a brown solid (2.90 g, 86%).

Sources & evidence

ORD record
ord-1092150280f044b5a6ccacc5a3ced7b5
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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