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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1265613Generated: October 28, 2026

Dimethyl isophthalate → 3-Tert-butoxycarbonylacetyl-benzoic acid methyl ester

https://huagongshe.com/reaction/1265613

Reaction equation

Participants

RoleNameHCIDCharge
ReactantDimethyl isophthalateHCID 15088—
ReactantLithium Tert-butyl AcetateHCID 86586795—
Product3-Tert-butoxycarbonylacetyl-benzoic acid methyl esterHCID 69688191—

Reaction Steps

Dimethyl isophthalate (67.9 g) was treated with lithium tert.-butyl acetate according to general procedure K (method b) to give crude 3-tert-butoxycarbonylacetyl-benzoic acid methyl ester (74.5 g) as a pale-yellow oil.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06544985B2
Source datasetuspto-grants-2003_04
ORD IDord-ca3467d9bac44fe092d49c7412ed859e
Source noteuspto-grants-2003_04