Dimethyl isophthalate → 3-Tert-butoxycarbonylacetyl-benzoic acid methyl ester

HRID 1265613Notes

Reaction equation

[C:1]([O:13]C)(=O)[C:2]1[CH:11]=[CH:10][CH:9]=[C:4]([C:5]([O:7][CH3:8])=[O:6])[CH:3]=1.[C:15]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])(=[O:17])[CH3:16].[Li]>>[CH3:8][O:7][C:5](=[O:6])[C:4]1[CH:9]=[CH:10][CH:11]=[C:2]([C:1](=[O:13])[CH2:16][C:15]([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17])[CH:3]=1

Participants

Reactant 2

HCID 15088Dimethyl isophthalate

HCID 86586795Lithium Tert-butyl Acetate

Product 1

HCID 696881913-Tert-butoxycarbonylacetyl-benzoic acid methyl ester

Procedure

Dimethyl isophthalate (67.9 g) was treated with lithium tert.-butyl acetate according to general procedure K (method b) to give crude 3-tert-butoxycarbonylacetyl-benzoic acid methyl ester (74.5 g) as a pale-yellow oil.

Sources & evidence

ORD record: ord-ca3467d9bac44fe092d49c7412ed859e
Source dataset: uspto-grants-2003_04
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06544985B2

Reaction notes

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