3-(2,5-Dimethyl-thiazol-4-yl)-benzoic acid methyl ester → 3-[3-(2,5-Dimethyl-thiazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

HRID 1265623Notes

Reaction equation

HRID 1265623 reaction equation
CO[C:3](=[O:17])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[C:12]([CH3:16])[S:13][C:14]=2[CH3:15])[CH:5]=1.[C:18]([O:21][C:22]([CH3:25])([CH3:24])[CH3:23])(=[O:20])[CH3:19].[Li]>>[C:22]([O:21][C:18](=[O:20])[CH2:19][C:3]([C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([C:10]2[N:11]=[C:12]([CH3:16])[S:13][C:14]=2[CH3:15])[CH:5]=1)=[O:17])([CH3:25])([CH3:24])[CH3:23]

Participants

3

Reactant 2

HCID 696879213-(2,5-Dimethyl-thiazol-4-yl)-benzoic acid methyl esterHCID 86586795Lithium Tert-butyl Acetate

Product 1

HCID 696881113-[3-(2,5-Dimethyl-thiazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester

Procedure

A sample of 3-(2,5-dimethyl-thiazol-4-yl)-benzoic acid methyl ester (0.99 g) was treated with lithium tert.-butyl acetate according to the general procedure K (method b) to give 3-[3-(2,5-dimethyl-thiazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (1.12 g) as a pale-yellow oil.

Sources & evidence

ORD record
ord-73206011a7e04c668bd0c9115fd32a87
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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