HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-(2,5-Dimethyl-thiazol-4-yl)-benzoic acid methyl ester → 3-[3-(2,5-Dimethyl-thiazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-(2,5-Dimethyl-thiazol-4-yl)-benzoic acid methyl ester | HCID 69687921 | — |
| Reactant | Lithium Tert-butyl Acetate | HCID 86586795 | — |
| Product | 3-[3-(2,5-Dimethyl-thiazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester | HCID 69688111 | — |
Reaction Steps
A sample of 3-(2,5-dimethyl-thiazol-4-yl)-benzoic acid methyl ester (0.99 g) was treated with lithium tert.-butyl acetate according to the general procedure K (method b) to give 3-[3-(2,5-dimethyl-thiazol-4-yl)-phenyl]-3-oxo-propionic acid tert-butyl ester (1.12 g) as a pale-yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-73206011a7e04c668bd0c9115fd32a87 |
| Source note | uspto-grants-2003_04 |