3-Cyanobenzoyl chloride → {4-Chloro-2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-5-dimethylamino-phenyl]-carbamic acid tert.-butyl ester

HRID 1265642노트

반응식

HRID 1265642 반응식
[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([Cl:17])=[CH:10][C:9]=1[NH2:18])([CH3:4])([CH3:3])[CH3:2].C([O:22][C:23](=O)[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]#[N:34])[CH:28]=1)=[O:26])C.C(C1C=C(C=CC=1)C(Cl)=O)#N>>[C:1]([O:5][C:6](=[O:19])[NH:7][C:8]1[CH:13]=[C:12]([N:14]([CH3:16])[CH3:15])[C:11]([Cl:17])=[CH:10][C:9]=1[NH:18][C:23](=[O:22])[CH2:24][C:25]([C:27]1[CH:32]=[CH:31][CH:30]=[C:29]([C:33]#[N:34])[CH:28]=1)=[O:26])([CH3:4])([CH3:2])[CH3:3]

참가 물질

4

반응물 3

HCID 3084833-Cyanobenzoyl chlorideHCID 11622629Ethyl 3-(3-cyanophenyl)-3-oxopropanoateHCID 69688689(2-Amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester

생성물 1

HCID 86586800{4-Chloro-2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-5-dimethylamino-phenyl]-carbamic acid tert.-butyl ester

실험 절차

The title compound was prepared from (2-amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester (Example J1) (0.5 mmol) and 3-(3-cyano-phenyl)-3-oxo-propionic acid ethyl ester [CAS-No. 62088-13-5; prepared from 3-cyanobenzoyl chloride according to general procedure K, method a] (0.55 mmol) according to the general procedure M. Obtained as a white solid (160 mg).

출처 및 근거

ORD 기록
ord-de55006ba641487cb84bdcf1def4e169
출처 데이터셋
uspto-grants-2003_04
특허 번호
US06544985B2

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