HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Cyanobenzoyl chloride → {4-Chloro-2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-5-dimethylamino-phenyl]-carbamic acid tert.-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Cyanobenzoyl chloride | HCID 308483 | — |
| Reactant | Ethyl 3-(3-cyanophenyl)-3-oxopropanoate | HCID 11622629 | — |
| Reactant | (2-Amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester | HCID 69688689 | — |
| Product | {4-Chloro-2-[3-(3-cyano-phenyl)-3-oxo-propionylamino]-5-dimethylamino-phenyl]-carbamic acid tert.-butyl ester | HCID 86586800 | — |
Reaction Steps
The title compound was prepared from (2-amino-4-chloro-5-dimethylamino-phenyl)-carbamic acid tert.-butyl ester (Example J1) (0.5 mmol) and 3-(3-cyano-phenyl)-3-oxo-propionic acid ethyl ester [CAS-No. 62088-13-5; prepared from 3-cyanobenzoyl chloride according to general procedure K, method a] (0.55 mmol) according to the general procedure M. Obtained as a white solid (160 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06544985B2 |
| Source dataset | uspto-grants-2003_04 |
| ORD ID | ord-de55006ba641487cb84bdcf1def4e169 |
| Source note | uspto-grants-2003_04 |