3-[3-(3-Methyl-isoxazol-5-yl)-phenyl)-3-oxo-propionic acid tert-butyl ester → HCID 86586819, compound

HRID 1265664Notes

Reaction equation

HRID 1265664 reaction equation
[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH2:14])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:27])([F:26])[F:25])[CH:9]=1)([CH3:4])([CH3:3])[CH3:2].C([O:33][C:34](=O)[CH2:35][C:36]([C:38]1[CH:43]=[CH:42][CH:41]=[C:40]([C:44]2[O:48][N:47]=[C:46]([CH3:49])[CH:45]=2)[CH:39]=1)=[O:37])(C)(C)C>>[C:1]([O:5][C:6](=[O:28])[NH:7][C:8]1[C:13]([NH:14][C:34](=[O:33])[CH2:35][C:36]([C:38]2[CH:43]=[CH:42][CH:41]=[C:40]([C:44]3[O:48][N:47]=[C:46]([CH3:49])[CH:45]=3)[CH:39]=2)=[O:37])=[CH:12][C:11]([C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][C:16]=2[F:21])=[C:10]([O:22][CH2:23][C:24]([F:25])([F:26])[F:27])[CH:9]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 695928713-[3-(3-Methyl-isoxazol-5-yl)-phenyl)-3-oxo-propionic acid tert-butyl esterHCID 69688642HCID 69688642, compound

Product 1

HCID 86586819HCID 86586819, compound

Procedure

The title compound was prepared from [5-amino-2′-fluoro-2-(2,2,2-trifluoro-ethoxy)-biphenyl-4-yl]-carbamic acid tert.-butyl ester (Example J5) (200 mg, 0.5 mmol) and 3-[3-(3-methyl-isoxazol-5-yl)-phenyl]-3-oxo-propionic acid tert.-butyl ester (Example K4) (160 mg, 0.53 mmol) according to the general procedure M. Obtained as a white solid (40 mg).

Sources & evidence

ORD record
ord-469c797593904a438ffaaa47291457ac
Source dataset
uspto-grants-2003_04
Patent number
US06544985B2

Reaction notes

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